You can safely use FRONTLINE® Plus on your Labrador, Golden Retriever or any other large breed puppy from as early as 8 weeks old. Rest assured that FRONTLINE® Plus will effectively terminate all fleas and most disease-causing ticks without hassle. The formulation contains fipronil, an active ingredient that attacks the nerve cells of the little busy bodies causing your dog to itch and scratch. They get hyperactive, disorientated and then they die. Combined with (S)-methoprene inhibiting insect growth, this is the perfect product to control tick and flea infestations for 30 days. Reapply this waterproof product monthly for continuous results and refrain from bathing your pet 3 days before and 3 days after treatment.